Distribution
Where the drug travels after the blood — protein binding, barriers, and volume of distribution.
Where Drugs Travel: Distribution & Plasma Protein Binding
Once a drug reaches the blood, the journey isn't over — it's just beginning. The bloodstream is a highway, but most of a drug never rides free: it hitches onto blood proteins like passengers strapped into seats, and only the few standing by the doors can actually step off and work. Understand who rides bound and who rides free, and you'll understand why one tiny new pill can suddenly make a patient on warfarin bleed.
Barriers, Reservoirs & Volume of Distribution
Why does an anaesthetic put a patient to sleep in one arm–brain circulation, then let them wake up minutes later — even though the drug is still in their body? Why can a single number, sometimes larger than the whole human body, tell you how big a starting dose to give? This is the strange, beautiful logic of barriers, hiding places, and the volume of distribution.
